Nanoparticle-Based Brain Targeted Delivery Systems
نویسندگان
چکیده
Presenting a very dismal prognosis, glioblastomas present as one of the most malignant brain tumors [1]. In addition to its low prognosis, glioblastomas account for ~70% of all astrocytic and oligodendroglial tumors, making this one of the most common types of brain tumors [1]. Through the mutations of multiple pro-oncogenic genes, primary glioblastomas develop as other neoplasms but present as “full-blown tumors” upon diagnosis, designating their development as de novo [1]. In contrast, because secondary glioblastomas develop through the progression of multiple low-grade and less malignant astrocytomas, they tend to differ from primary glioblastomas in development, the expression of various proteins, and responses to therapy [1]. Attempts at therapeutic intervention fall prey to blockages by the blood-brain barrier (BBB).
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